Numerical prediction of drug release from polyurethane samples combining kinetic model developed by experimental data

With the aim of optimizing Drug Eluting Stents (DES), particular attention has been laid on computational methods controlling drug release profile among researchers. Consequently, various models and simulations are available in literature. Nevertheless, validations based biorelevant in-vitro trials lacking. In present study, a comparison from polyurethane samples between calculated results experimental-data carried out. The calculation numerical simulation newly established mathematical model for reproducing liberation kinetic. Different fluid flow rates initial concentrations polymer have taken into account.